Low Dose Naltrexone works by boosting levels of endorphins (a substance the body produces in the brain and adrenal glands) – endogenous opioid production - that is best known for relieving pain and enhancing your sense of well-being, which leads to several therapeutic effects. In particular, the drug has an effect on the production of endorphins like Opiate Growth Factor, which influences cell growth and immunity.

Low Dose Naltrexone blocks receptors for only a few hours after which it is excreted naturally. The low dosage of naltrexone produces a “rebound” effect that persists for about one day. Once the medication leaves the body, the highly sensitized receptors can better utilize the extra endorphins produced. Low Dose Naltrexone leads to both better production of Opiate Growth Factor and more efficient utilization.

Low Dose Naltrexone, taken at bedtime, attaches to opioid receptors in the brain and in all types of immune cells, which temporarily blocks endorphins from attaching to them. This signals your body to increase endorphin production. The increased endorphin production helps orchestrate the activity of stem cells, macrophages, natural killer cells, T and B cells and other immune cells. It also prevents immune system overactivity.

Low Dose Naltrexone requires a prescription from a physician and is available only from a compounding pharmacy. Low Dose Naltrexone is taken daily to maintain healthy immune system functioning, and its effects are long-lasting. In many references it is recommended that the naltrexone preparation to be taken at bedtime, as this is the optimal time for the drug to sync with your body’s hormone activity. However, if you experience sleep disturbances while taking Low Dose Naltrexone, it can still be effective taken earlier in the day. It is also recommended to start with a dose of 1.5mg and build up slowly over two months.